It is exposed this Mini-Review where is evidenced the internal origin of the stress and its continuity, from there until to its terminal pathogenic effect of different intensity, structure and non-specificity. It can be observed into that analysis, the different conceptions about emotion and stress, and how is develop into the pattern generality-singularity-generality. Thus, the conclusion is that the relationship of emotion-stress becomes a system according the model stressor-emotional arousal-stress-dysfunction.